How to handle large number of users

I am investigating the possibility to write a server side application to handle a large number of requests. The maximum number of users is estimated to be 10 million.

The application has to update few database tables once a day.

I have never done anything big like this before and was wondering if it would be possible to develop such an application using Delphi(Win32). What technologies would be best suited to handle such a big load?
What database should I use?

Regards

Sandeep
.

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