Working with data that has multiple columns and rows

I tried to read a book and articles on the web about this issue, but
no luck so far.
I am wondering if somebody can help me figure out what the sort of the
standard way to treat the data with multiple columns and rows is.

For example, I have data (numbers and strings) in which I have 5
columns with descriptions on the top line and 1000 rows. I would like
to know how to first read into this data and treat each element of the
data in a vector format.

Thanks in advance.

.

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