Searching large files with a regex and a list

Hello All -

I would like some suggestions (constructive) on some code I'm writing.
My Perl is rusty and that's reflected in the sample I'm posting. Here
is what I have to tackle. I have Gig files to parse for two different
RegEx's. Within those RegEx's there is a variable that is a list of
18,000+ numbers. I'm looking for some suggestions on what I can do to
speed things up, or at least make things better.

Thanks in advance for your time.

------- Code Begin ---------
#!/usr/bin/perl

my $match=0;
my $nonMatch=0;

open(DN_LIST, "<","big_list");
my @list = <DN_LIST>;
@list=sort(@list);
close(DN_LIST);
foreach (@list)
{
chomp;
s/ //g;
}
@list = join('|',@list);


while (<>)
{
if ( /^123456\d{8}($list[0])/o or /^9876(91|92)\d{24}($list[0])/o )
{
$match++;
}
else
{
$nonMatch++;
}
}

print "Match Count:" . ${match} . "\n";
print "Non-Match Count:" . ${nonMatch} . "\n";

------- Code End ---------

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